Simultaneous determination of serotonin, dopamine, and ascorbic acid at a glassy carbon electrode modified with chitosan-alginate hydrogel and reduced graphene oxide

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dc.citation.rankM21
dc.citation.spage118992
dc.citation.volume980
dc.contributor.authorPostolović, Katarina S.
dc.contributor.authorRadovanović, Milan B.
dc.contributor.authorStanić, Zorka D.
dc.date.accessioned2025-08-26T08:14:03Z
dc.date.available2025-08-26T08:14:03Z
dc.date.issued2025
dc.description.abstractDetection of biologically active components, such as ascorbic acid, dopamine, and serotonin, is significant from the perspective of biomedicine, particularly in the process of disease diagnosis and in the quality control of commercial pharmaceutical products. In this work, a novel electrochemical sensor was developed by modifying a glassy carbon electrode with a hydrogel composed of a polyelectrolyte complex of alginate and chitosan, along with the addition of electrochemically reduced graphene oxide. This biocompatible sensor was applied for the simultaneous determination of ascorbic acid, dopamine, and serotonin using adsorptive square wave voltammetry. The modified GCE demonstrated an excellent electrochemical response towards the target analytes, thanks to the enhanced adsorption of the analytes on the surface of the electrode, facilitated by favorable interactions between analytes and the modifiers. This approach increased the electrode’s active surface area and ensured excellent electrode response. The sensor exhibited a broad linear range of the anodic current relative to analyte concentration, achieving low detection limits of 0.094 μM, 4.18 nM and 3.23 nM for ascorbic acid, dopamine and serotonin, respectively. Additionally, the proposed sensor exhibited good stability, reproducibility of results, selectivity, as well as effectiveness, in the determination of target biological compounds in real sample matrices.
dc.identifier.doi10.1016/j.jelechem.2025.118992
dc.identifier.issn1572-6657
dc.identifier.urihttps://repozitorijum.tfbor.bg.ac.rs/handle/123456789/5994
dc.language.isoen
dc.publisherElsevier
dc.rights.licenseARR
dc.rights.uriAll rights reserved
dc.sourceJournal of Electroanalytical Chemistry
dc.subjectDopamine
dc.subjectSerotonin
dc.subjectAscorbic acid
dc.subjectChitosan-alginate hydrogel
dc.subjectGraphene oxide
dc.subjectVoltammetric sensor
dc.titleSimultaneous determination of serotonin, dopamine, and ascorbic acid at a glassy carbon electrode modified with chitosan-alginate hydrogel and reduced graphene oxide
dc.typearticle
dc.type.versionpublishedVersion

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